In the presence of conducting inhomogeneities in near-surface structures, apparent resistivity data in magnetotelluric sounding can be severely distorted.This is due to electric fields generated from boundary charges on surficial inhomogeneities.Such distortion persists throughout the entire recording range and is known as static shift in magnetote
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation.We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNAcylation of DNMT1 from high glucose environment leads to alterations to the epigenome.Using mass spec
Abstract Background Anthracyclines are a mainstay of chemotherapy.However, a relatively frequent adverse outcome of anthracycline treatment is cardiomyopathy.Multiple genetic studies have begun to dissect the complex genetics underlying cardiac sensitivity to the anthracycline drug class.A number of single nucleotide polymorphisms (SNPs) have been